Abstract:

Lyme Disease is the most common vector-borne illness in the U.S. and presents serious public health risks throughout the northern U.S. and Canada. This illness, caused by the bacterial pathogen Borrelia burgdorferi and transmitted primarily by black-legged ticks (Ixodes scapularis), presents unique challenges for infectious disease models, as well as unique opportunities for public health interventions. The pathogen is maintained in the environment thanks to a complex interaction of vector and reservoir animal species, over multiple tick life-stages and seasons. Interventions must therefore seek to interrupt the transmission to incidental hosts (humans and domestic dogs) – a strategy which has primarily focused on prevention of exposure to the tick vector. In this work, we present two related analyses. First, we explore new evidence for the mechanisms by which transfer of the infectious agent can be interrupted in mouse populations. Second, we apply these findings to develop an improved Bayesian ecological model of data from a prior reservoir vaccination study. Finally, we’ll explore the implications for interventions, and describe ongoing efforts to better understand the impact of these processes on human health.

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Topic: Colloquia: Department of Statistics and Actuarial Science, The University of Iowa

Time: Oct 22, 2020 03:15 PM Central Time (US and Canada)

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Meeting ID: 970 2130 9544